Signs and symptoms

• Absence of bony covering over the back of the head

• Missing bones around the front and sides of the head

• Folding of the ears

• Cleft palate--a condition in which the roof of the child's mouth doesn't completely close, leaving an opening that can extend into the nasal cavity.

• Congenital heart defects

• Absence of brain tissue and bony calvarium

• A "Frog eye" appearance upon coronal section of the face.

Born without skull and brain.